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ENTRY EC 1.1.1.6 NAME glycerol dehydrogenase glycerin dehydrogenase NAD-linked glycerol dehydrogenase CLASS Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor SYSNAME glycerol:NAD 2-oxidoreductase REACTION glycerol + NAD = glycerone + NADH2 SUBSTRATE glycerol NAD PRODUCT NADH glycerone COMMENT Also acts on propane-1,2-diol. REFERENCE 1 Asnis, R.E. and Brodie, A.F. A glycerol dehydrogenase from Escherichia coli. J. Biol. Chem. 203 (1953) 153-159. 2 Burton, R.M. and Kaplan, N.O. A DPN specific glycerol dehydrogenase from Aerobacter aerogenes. J. Am. Chem. Soc. 75 (1953) 1005-1007. 3 Lin, E.C.C. and Magasanik, B. The activation of glycerol dehydrogenase from Aerobacter aerogenes by monovalent cations. J. Biol. Chem. 235 (1960) 1820-1823. PATHWAY PATH: MAP00561 Glycerolipid metabolism ORTHOLOG KO: K00005 glycerol dehydrogenase GENES SPO: SPAC13F5.03c ECO: b3945(gldA) ECJ: JW3917(gldA) ECE: Z5500(gldA) ECS: ECs4874 ECC: c4904(gldA) STY: STY3759(gldA) STM: STM3529 STM4108(gldA) VPA: VP0363 SME: SMc02038(gldA) OIH: OB0323 OB3328 SEP: SE0235 SPY: SPy2047(gldA) SPM: spyM18_2108(gldA) SPG: SpyM3_1747(gldA) SPN: SP0253 SPR: spr0234(gldA) SAG: SAG0333(gldA) SAG2046 SAN: gbs0321 gbs2002 SMU: SMU.1309c SMU.495(gldA) CPE: CPE0099(gldA) CTC: CTC00596 SYN: slr1167(gldA) TEL: tll2051(gldA) ANA: alr2764 TMA: TM0423 HAL: VNG6270G(gldA) MOTIF PS: PS00060 [GSW]-x-[LIVTSACD]-[GH]-x(2)-[GSAE]-[GSHYQ]-x-[LIVTP]- [GAST]-[GAS]-x(3)-[LIVMT]-x-[HNS]-[GA]-x-[GTAC] PS: PS00913 [STALIV]-[LIVF]-x-[DE]-x(6,7)-P-x(4)-[ALIV]-x-[GST]- x(2)-D-[TAIVM]-[LIVMF]-x(4)-E STRUCTURES PDB: 1JQ5 1JQA 1JPU DBLINKS IUBMB Enzyme Nomenclature: 1.1.1.6 ExPASy - ENZYME nomenclature database: 1.1.1.6 WIT (What Is There) Metabolic Reconstruction: 1.1.1.6 BRENDA, the Enzyme Database: 1.1.1.6 SCOP (Structural Classification of Proteins): 1.1.1.6 CAS: 9028-14-2 ///

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